Atsuo T Sasaki Selected Research

Guanosine Triphosphate (GTP)

1/2022	SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides.
10/2020	GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism.
1/2020	Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells.
9/2019	Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.
1/2019	Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma.
10/2016	Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells.
1/2016	The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
1/2016	Dynamic Role of the GTP Energy Metabolism in Cancers.
2/2014	Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.

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Atsuo T Sasaki Research Topics

Disease

24	Neoplasms (Cancer) 01/2021 - 09/2008
7	Carcinogenesis 09/2019 - 09/2008
5	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2017
4	Neoplasm Metastasis (Metastasis) 01/2021 - 06/2011
3	Lung Neoplasms (Lung Cancer) 01/2021 - 12/2011
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 04/2012
2	Prostatic Neoplasms (Prostate Cancer) 06/2011 - 09/2008
1	Disease Progression 10/2021
1	Stomach Neoplasms (Stomach Cancer) 01/2021
1	Hypertrophy 01/2019
1	Brain Neoplasms (Brain Tumor) 01/2019
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2019
1	Leukemia 11/2018
1	Starvation 11/2016
1	Metabolic Diseases (Metabolic Disease) 01/2016
1	Breast Neoplasms (Breast Cancer) 11/2013
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 05/2010

Drug/Important Bio-Agent (IBA)

9	Guanosine Triphosphate (GTP)IBA 01/2022 - 02/2014
7	EnzymesIBA 01/2021 - 12/2011
5	Phosphotransferases (Kinase)IBA 01/2016 - 01/2013
4	Inosine Monophosphate (IMP)IBA 10/2020 - 01/2019
3	NucleotidesIBA 01/2020 - 01/2019
3	purineIBA 01/2020 - 01/2019
3	LipidsIBA 01/2016 - 04/2012
2	Transfer RNA (tRNA)IBA 01/2022 - 01/2019
2	phosphatidylinositol 5-phosphateIBA 03/2020 - 11/2013
2	Oxidoreductases (Dehydrogenase)IBA 09/2019 - 01/2019
2	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2013 - 01/2013
1	Messenger RNA (mRNA)IBA 01/2022
1	VaccinesIBA 01/2021
1	PlatinumIBA 01/2021
1	Amino Acids FDA Link 01/2021
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2021
1	RNA Polymerase I (Polymerase I, RNA)IBA 10/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 09/2019
1	IMP DehydrogenaseIBA 09/2019
1	GMP synthase (glutamine-hydrolyzing)IBA 01/2019
1	NM23 Nucleoside Diphosphate KinasesIBA 01/2019
1	Guanylate KinasesIBA 01/2019
1	guanosine 5'-monophosphorothioateIBA 01/2019
1	Guanine NucleotidesIBA 01/2019
1	6-methyladenineIBA 11/2018
1	N-methyladenosineIBA 11/2018
1	Alpha-Ketoglutarate-Dependent Dioxygenase FTOIBA 11/2018
1	RNA (Ribonucleic Acid)IBA 11/2018
1	N- (4- (2- amino- 3- chloropyridin- 4- yloxy)- 3- fluorophenyl)- 4- ethoxy- 1- (4- fluorophenyl)- 2- oxo- 1,2- dihydropyridine- 3- carboxamideIBA 01/2017
1	SphingolipidsIBA 11/2016
1	Biological ProductsIBA 01/2016
1	PlasticsIBA 11/2013
1	GTP Phosphohydrolases (GTPases)IBA 01/2013
1	Protein Isoforms (Isoforms)IBA 01/2013
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2012
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 04/2012
1	Coenzyme A (CoA)IBA 04/2012
1	ErbB Receptors (EGF Receptor)IBA 04/2012
1	CholesterolIBA 04/2012
1	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA 04/2012
1	Mitogen-Activated Protein KinasesIBA 04/2012
1	Cytostatic AgentsIBA 04/2012
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 04/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2011
1	Pyruvate KinaseIBA 12/2011
1	Lactic Acid (Lactate)FDA LinkGeneric 07/2011
1	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 07/2011
1	IsotopesIBA 07/2011
1	Glucose (Dextrose)FDA LinkGeneric 07/2011
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 07/2011
1	Serine (L-Serine)FDA Link 07/2011
1	CarbonIBA 07/2011
1	Ubiquitin-Conjugating EnzymesIBA 06/2011
1	Chemotactic FactorsIBA 05/2010
1	ras Guanine Nucleotide Exchange FactorsIBA 05/2010
1	Mechanistic Target of Rapamycin Complex 2IBA 05/2010
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 05/2010
1	Actins (F Actin)IBA 05/2010
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 05/2010
1	GuanineIBA 05/2010
1	TOR Serine-Threonine KinasesIBA 09/2008
1	Everolimus FDA Link 09/2008
1	Mechanistic Target of Rapamycin Complex 1IBA 09/2008
1	Sirolimus (Rapamycin)FDA Link 09/2008

Therapy/Procedure

7	Therapeutics 10/2021 - 03/2012
3	Drug Therapy (Chemotherapy) 01/2021 - 09/2012